Its been confirmed that all enemies and items will be randomized during each playthrough to maximize replayability.

This seems like not just a good idea to maxmize game time, but a good way to maximize scares and tension.

Resident Evil: Revelations will be released by Capcom on May 21st in North America, May 23rd in Japan and May 24th in Europe. It will be released for the Xbox 360, Playstation 3, Nintendo WiiU, and PC.